Niches, population structure and genome reduction in Ochrobactrum intermedium: clues to technology-driven emergence of pathogens.

ABSTRACT: Ochrobactrum intermedium is considered as an emerging human environmental opportunistic pathogen with mild virulence. The distribution of isolates and sequences described in literature and databases showed frequent association with human beings and polluted environments. As population structures are related to bacterial lifestyles, we investigated by multi-locus approach the genetic structure of a population of 65 isolates representative of the known natural distribution of O. intermedium. The population was further surveyed for genome dynamics using pulsed-field gel electrophoresis and genomics. The population displayed a clonal epidemic structure with events of recombination that occurred mainly in clonal complexes. Concerning biogeography, clones were shared by human and environments an

SUBMITTER: Aujoulat F 

PROVIDER: S-EPMC3894950 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature