Global state measures of the dentate gyrus gene expression system predict antidepressant-sensitive behaviors.

ABSTRACT:

Background

Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are the most common form of medication treatment for major depression. However, approximately 50% of depressed patients fail to achieve an effective treatment response. Understanding how gene expression systems respond to treatments may be critical for understanding antidepressant resistance.

Methods

We take a novel approach to this problem by demonstrating that the gene expression system of the dentate gyrus responds to fluoxetine (FLX), a commonly used antidepressant medication, in a stereotyped-manner involving changes in the expression levels of thousands of genes. The aggregate behavior of this large-scale systemic response was quantified with principal components analysis (PCA) yielding a sin

SUBMITTER: Samuels BA 

PROVIDER: S-EPMC3894967 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature