Estimation of parameters in the two-compartment model for exhaled nitric oxide.

ABSTRACT: The fractional concentration of exhaled nitric oxide (FeNO) is a biomarker of airway inflammation that is being increasingly considered in clinical, occupational, and epidemiological applications ranging from asthma management to the detection of air pollution health effects. FeNO depends strongly on exhalation flow rate. This dependency has allowed for the development of mathematical models whose parameters quantify airway and alveolar compartment contributions to FeNO. Numerous methods have been proposed to estimate these parameters using FeNO measured at multiple flow rates. These methods--which allow for non-invasive assessment of localized airway inflammation--have the potential to provide important insights on inflammatory mechanisms. However, different estimation methods produce dif

SUBMITTER: Eckel SP 

PROVIDER: S-EPMC3894971 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature