Capturing intracellular pH dynamics by coupling its molecular mechanisms within a fully tractable mathematical model.

ABSTRACT: We describe the construction of a fully tractable mathematical model for intracellular pH. This work is based on coupling the kinetic equations depicting the molecular mechanisms for pumps, transporters and chemical reactions, which determine this parameter in eukaryotic cells. Thus, our system also calculates the membrane potential and the cytosolic ionic composition. Such a model required the development of a novel algebraic method that couples differential equations for slow relaxation processes to steady-state equations for fast chemical reactions. Compared to classical heuristic approaches based on fitted curves and ad hoc constants, this yields significant improvements. This model is mathematically self-consistent and allows for the first time to establish analytical solutions for st

SUBMITTER: Bouret Y 

PROVIDER: S-EPMC3894979 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature