Replication of breast cancer susceptibility loci in whites and African Americans using a Bayesian approach.

ABSTRACT: Genome-wide association studies (GWAS) and candidate gene analyses have led to the discovery of several dozen genetic polymorphisms associated with breast cancer susceptibility, many of which are considered well-established risk factors for the disease. Despite attempts to replicate these same variant-disease associations in African Americans, the evaluable populations are often too small to produce precise or consistent results. We estimated the associations between 83 previously identified single nucleotide polymorphisms (SNPs) and breast cancer among Carolina Breast Cancer Study (1993-2001) participants using maximum likelihood, Bayesian, and hierarchical methods. The selected SNPs were previous GWAS hits (n = 22), near-hits (n = 19), otherwise well-established risk loci (n = 5), or loc

SUBMITTER: O'Brien KM 

PROVIDER: S-EPMC3895095 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature