N-Glycosylation of GABAA receptor subunits is altered in Schizophrenia.

ABSTRACT: The molecular mechanisms of schizophrenia have been under investigation for decades; however, the exact causes of this debilitating neuropsychiatric disorder are still unknown. Previous studies have identified multiple affected neurotransmitter systems, brain regions, and cell types, each making a unique contribution to symptom presentation and pathophysiology. Numerous studies have identified gene and protein expression changes in schizophrenia, but the role of post-translational modifications, specifically N-glycosylation, has only recently become a target of investigation. N-glycosylation of molecules associated with glutamatergic neurotransmission is disrupted in schizophrenia, but it was unknown if these alterations are exclusive to the glutamatergic system or due to a more generalize

SUBMITTER: Mueller TM 

PROVIDER: S-EPMC3895232 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature