Population pharmacokinetic and pharmacogenetic analysis of tacrolimus in paediatric liver transplant patients.

ABSTRACT:

Aims

To build a population pharmacokinetic model that describes the apparent clearance of tacrolimus and the potential demographic, clinical and genetically controlled factors that could lead to inter-patient pharmacokinetic variability within children following liver transplantation.

Methods

The present study retrospectively examined tacrolimus whole blood pre-dose concentrations (n = 628) of 43 children during their first year post-liver transplantation. Population pharmacokinetic analysis was performed using the non-linear mixed effects modelling program (nonmem) to determine the population mean parameter estimate of clearance and influential covariates.

Results

The final model identified time post-transplantation and CYP3A5*1 allele as influential covariates on ta

SUBMITTER: Jalil MH 

PROVIDER: S-EPMC3895354 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature