High-throughput microRNA profiling of pediatric high-grade gliomas.

ABSTRACT:

Background

High-grade gliomas (HGGs) account for 15% of all pediatric brain tumors and are a leading cause of cancer-related mortality and morbidity. Pediatric HGGs (pHGGs) are histologically indistinguishable from their counterpart in adulthood. However, recent investigations indicate that differences occur at the molecular level, thus suggesting that the molecular path to gliomagenesis in childhood is distinct from that of adults. MicroRNAs (miRNAs) have been identified as key molecules in gene expression regulation, both in development and in cancer. miRNAs have been investigated in adult high-grade gliomas (aHGGs), but scant information is available for pHGGs.

Methods

We explored the differences in microRNAs between pHGG and aHGG, in both fresh-frozen and paraffin-embedd

SUBMITTER: Miele E 

PROVIDER: S-EPMC3895388 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature