Shining a light on CNTNAP2: complex functions to complex disorders.

ABSTRACT: The genetic basis of complex neurological disorders involving language are poorly understood, partly due to the multiple additive genetic risk factors that are thought to be responsible. Furthermore, these conditions are often syndromic in that they have a range of endophenotypes that may be associated with the disorder and that may be present in different combinations in patients. However, the emergence of individual genes implicated across multiple disorders has suggested that they might share similar underlying genetic mechanisms. The CNTNAP2 gene is an excellent example of this, as it has recently been implicated in a broad range of phenotypes including autism spectrum disorder (ASD), schizophrenia, intellectual disability, dyslexia and language impairment. This review considers the ev

SUBMITTER: Rodenas-Cuadrado P 

PROVIDER: S-EPMC3895625 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature