A panel of ancestry informative markers to estimate and correct potential effects of population stratification in Han Chinese.

ABSTRACT: Population stratification acts as a confounding factor in genetic association studies and may lead to false-positive or false-negative results. Previous studies have analyzed the genetic substructures in Han Chinese population, the largest ethnic group in the world comprising ∼20% of the global human population. In this study, we examined 5540 Han Chinese individuals with about 1 million single-nucleotide polymorphisms (SNPs) and screened a panel of ancestry informative markers (AIMs) to facilitate the discerning and controlling of population structure in future association studies on Han Chinese. Based on genome-wide data, we first confirmed our previous observation of the north-south differentiation in Han Chinese population. Second, we developed a panel of 150 validated SNP AIMs to dete

SUBMITTER: Qin P 

PROVIDER: S-EPMC3895631 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature