Bifacial PNA complexation inhibits enzymatic access to DNA and RNA.

ABSTRACT: FULL STOP: Herein we report the effective in vitro inhibition of transcription, reverse-transcription and exonuclease function by formation of synthetic bPNA-nucleic acid triplex structures. Selective bPNA targeting of both DNA and RNA substrates suggests possible application of bPNAs as synthetic regulators of nucleic acid function.

SUBMITTER: Xia X 

PROVIDER: S-EPMC3896088 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature