The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system.

ABSTRACT: Type III secretion machines are essential for the biology of many bacteria that are pathogenic or symbiotic for animals, plants, or insects. They exert their function by delivering bacterial effector proteins into target eukaryotic cells. The core component of these machines is the needle complex, a multiprotein structure that spans the bacterial envelope and serves as a conduit for proteins that transit this secretion pathway. The needle complex is composed of a multiring base embedded in the bacterial envelope and a filament-like structure, the needle, that projects from the bacterial surface and is linked to the base by the inner rod. Assembly of the needle complex proceeds in a step-wise fashion that is initiated by the assembly of the base and is followed by the export of the building

SUBMITTER: Lefebre MD 

PROVIDER: S-EPMC3896146 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature