Genome wide expression profiling during spinal cord regeneration identifies comprehensive cellular responses in zebrafish.

ABSTRACT:

Background

Among the vertebrates, teleost and urodele amphibians are capable of regenerating their central nervous system. We have used zebrafish as a model to study spinal cord injury and regeneration. Relatively little is known about the molecular mechanisms underlying spinal cord regeneration and information based on high density oligonucleotide microarray was not available. We have used a high density microarray to profile the temporal transcriptome dynamics during the entire phenomenon.

Results

A total of 3842 genes expressed differentially with significant fold changes during spinal cord regeneration. Cluster analysis revealed event specific dynamic expression of genes related to inflammation, cell death, cell migration, cell proliferation, neurogenesis, neural pattern

SUBMITTER: Hui SP 

PROVIDER: S-EPMC3896338 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature