Evolutionary conservation of divergent pro-inflammatory and homeostatic responses in Lamprey phagocytes.

ABSTRACT: In higher vertebrates, phagocytosis plays a critical role in development and immunity, based on the internalization and removal of apoptotic cells and invading pathogens, respectively. Previous studies describe the effective uptake of these particles by lower vertebrate and invertebrate phagocytes, and identify important molecular players that contribute to this internalization. However, it remains unclear if individual phagocytes mediate internalization processes in these ancient organisms, and how this impacts the balance of pro-inflammatory and homeostatic events within their infection sites. Herein we show that individual phagocytes of the jawless vertebrate Petromyzon marinus (sea lamprey), like those of teleost fish and mice, display the capacity for divergent pro-inflammatory and ho

SUBMITTER: Havixbeck JJ 

PROVIDER: S-EPMC3896464 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature