Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys.

ABSTRACT: Antibody interactions with Fcγ receptors (FcγRs), like FcγRIIIA, play a critical role in mediating antibody effector functions and thereby contribute significantly to the biologic and therapeutic activity of antibodies. Over the past decade, considerable work has been directed towards production of antibodies with altered binding affinity to FcγRs and evaluation of how the alterations modulate their therapeutic activity. This has been achieved by altering glycosylation status at N297 or by engineering modifications in the crystallizable fragment (Fc) region. While the effects of these modifications on biologic activity and efficacy have been examined, few studies have been conducted to understand their effect on antibody pharmacokinetics (PK). We present here a retrospective analysis in wh

SUBMITTER: Leabman MK 

PROVIDER: S-EPMC3896603 | biostudies-literature | 2013 Nov-Dec

REPOSITORIES: biostudies-literature