Juvenile methylphenidate reduces prefrontal cortex plasticity via D3 receptor and BDNF in adulthood.

ABSTRACT:

Background

Early drug intervention in childhood disorders aims to maximize individual potential in the short- and long-term. Consistently, juvenile exposure to psychostimulants, such as methylphenidate (MPH), reduces risk for substance use in animals and sub-populations of individuals with attention deficit hyperactivity disorder (ADHD). We investigated the effects of MPH on brain plasticity via dopamine receptor D3 (D3R) and brain-derived neurotrophic factor (BDNF) expression in developing rats.

Methods

Between postnatal days 20-35, rat pups were administered saline vehicle (Veh) or MPH (2 mg/kg), the D3R-preferring agonist ±7-OHDPAT, or the antagonist nafadotride (0.05 mg/kg) alone, or in combination with MPH twice a day. In adulthood, subjects were challenged to Veh or co

SUBMITTER: Andersen SL 

PROVIDER: S-EPMC3896878 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature