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Nontypeable Streptococcus pneumoniae as an otopathogen.

ABSTRACT: Among 34 Streptococcus pneumoniae (Spn) sequential isolates from middle ear fluid, we found a case of a nontypeable S. pneumoniae (NT-Spn) in a child with acute otitis media (AOM). The strain was pneumolysin PCR positive and capsule gene PCR negative. Virulence of the NT-Spn was confirmed in a chinchilla model of AOM.

SUBMITTER: Xu Q 

PROVIDER: S-EPMC3897191 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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Nontypeable Streptococcus pneumoniae as an otopathogen.

Xu Qingfu Q   Kaur Ravinder R   Casey Janet R JR   Sabharwal Vishakha V   Pelton Stephen S   Pichichero Michael E ME  

Diagnostic microbiology and infectious disease 20110201 2

Among 34 Streptococcus pneumoniae (Spn) sequential isolates from middle ear fluid, we found a case of a nontypeable S. pneumoniae (NT-Spn) in a child with acute otitis media (AOM). The strain was pneumolysin PCR positive and capsule gene PCR negative. Virulence of the NT-Spn was confirmed in a chinchilla model of AOM. ...[more]