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The ins and outs of hepatitis C virus entry and assembly.


ABSTRACT: Hepatitis C virus, a major human pathogen, produces infectious virus particles with several unique features, such as an ability to interact with serum lipoproteins, a dizzyingly complicated process of virus entry, and a pathway of virus assembly and release that is closely linked to lipoprotein secretion. Here, we review these unique features, with an emphasis on recent discoveries concerning virus particle structure, virus entry and virus particle assembly and release.

SUBMITTER: Lindenbach BD 

PROVIDER: S-EPMC3897199 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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The ins and outs of hepatitis C virus entry and assembly.

Lindenbach Brett D BD   Rice Charles M CM  

Nature reviews. Microbiology 20130910 10


Hepatitis C virus, a major human pathogen, produces infectious virus particles with several unique features, such as an ability to interact with serum lipoproteins, a dizzyingly complicated process of virus entry, and a pathway of virus assembly and release that is closely linked to lipoprotein secretion. Here, we review these unique features, with an emphasis on recent discoveries concerning virus particle structure, virus entry and virus particle assembly and release. ...[more]

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