Evaluation of American Joint Committee on Cancer, International Union Against Cancer, and Brigham and Women's Hospital tumor staging for cutaneous squamous cell carcinoma.

ABSTRACT:

Purpose

To compare American Joint Committee on Cancer (AJCC), International Union Against Cancer (UICC), and Brigham and Women's Hospital (BWH) tumor (T) staging systems for cutaneous squamous cell carcinoma and validate BWH staging against prior data.

Patients and methods

Primary tumors diagnosed from 2000 to 2009 at BWH (n = 1,818) were analyzed. Poor outcomes (local recurrence [LR], nodal metastasis [NM], and disease-specific death [DSD]) were analyzed by T stage with regard to each staging system's distinctiveness (outcome differences between stages), homogeneity (outcome similarity within stages), and monotonicity (outcome worsening with increasing stage).

Results

AJCC and UICC T3 and T4 were indistinct with overlapping 95% CIs for 10-year cumulative incidences o

SUBMITTER: Karia PS 

PROVIDER: S-EPMC3897257 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature