Daily intermittent hypoxia enhances walking after chronic spinal cord injury: a randomized trial.

ABSTRACT:

Objectives

To test the hypothesis that daily acute intermittent hypoxia (dAIH) and dAIH combined with overground walking improve walking speed and endurance in persons with chronic incomplete spinal cord injury (iSCI).

Methods

Nineteen subjects completed the randomized, double-blind, placebo-controlled, crossover study. Participants received 15, 90-second hypoxic exposures (dAIH, fraction of inspired oxygen [Fio2] = 0.09) or daily normoxia (dSHAM, Fio2 = 0.21) at 60-second normoxic intervals on 5 consecutive days; dAIH was given alone or combined with 30 minutes of overground walking 1 hour later. Walking speed and endurance were quantified using 10-Meter and 6-Minute Walk Tests. The trial is registered at ClinicalTrials.gov (NCT01272349).

Results

dAIH improved walkin

SUBMITTER: Hayes HB 

PROVIDER: S-EPMC3897437 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature