Expression variants of the lipogenic AGPAT6 gene affect diverse milk composition phenotypes in Bos taurus.

ABSTRACT: Milk is composed of a complex mixture of lipids, proteins, carbohydrates and various vitamins and minerals as a source of nutrition for young mammals. The composition of milk varies between individuals, with lipid composition in particular being highly heritable. Recent reports have highlighted a region of bovine chromosome 27 harbouring variants affecting milk fat percentage and fatty acid content. We aimed to further investigate this locus in two independent cattle populations, consisting of a Holstein-Friesian x Jersey crossbreed pedigree of 711 F2 cows, and a collection of 32,530 mixed ancestry Bos taurus cows. Bayesian genome-wide association mapping using markers imputed from the Illumina BovineHD chip revealed a large quantitative trait locus (QTL) for milk fat percentage on chromos

SUBMITTER: Littlejohn MD 

PROVIDER: S-EPMC3897493 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature