Compartmental and temporal dynamics of chronic inflammation and airway remodelling in a chronic asthma mouse model.

ABSTRACT:

Background

Allergic asthma is associated with chronic airway inflammation and progressive airway remodelling. However, the dynamics of the development of these features and their spontaneous and pharmacological reversibility are still poorly understood. We have therefore investigated the dynamics of airway remodelling and repair in an experimental asthma model and studied how pharmacological intervention affects these processes.

Methods

Using BALB/c mice, the kinetics of chronic asthma progression and resolution were characterised in absence and presence of inhaled corticosteroid (ICS) treatment. Airway inflammation and remodelling was assessed by the analysis of bronchoalveolar and peribronichal inflammatory cell infiltrate, goblet cell hyperplasia, collagen deposition and

SUBMITTER: Alrifai M 

PROVIDER: S-EPMC3897544 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature