A pooled analysis of injection site-related adverse events in patients with schizophrenia treated with olanzapine long-acting injection.

ABSTRACT:

Background

Depot antipsychotic injections are an important tool for the management of patients with schizophrenia who have difficulty with adherence to oral medication. However, pain and discomfort at the injection site can be a potential impediment to the use of these long-acting formulations. We report here the results of a pooled analysis of injection site-related adverse events (AEs) collected during treatment with the olanzapine long-acting injection (olanzapine LAI).

Methods

Unsolicited injection site-related AEs were pooled from 7 olanzapine LAI clinical trials conducted in patients between March 2001 and December 2010. All patients had a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) or Fourth Edition, Text Revision (DSM-IV-TR) diagnos

SUBMITTER: Atkins S 

PROVIDER: S-EPMC3897927 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature