Neural and behavioral effects of a novel mu opioid receptor antagonist in binge-eating obese people.

ABSTRACT:

Background

Binge eating is associated with obesity and has been conceptualized as "food addiction." However, this view has received only inconsistent support in humans, and limited evidence relates key neurocircuitry to the disorder. Moreover, relatively few studies have used pharmacologic functional magnetic resonance imaging to probe the underlying basis of altered eating behaviors.

Methods

In a double-blind, placebo-controlled, parallel group study, we explored the effects of a potent mu-opioid receptor antagonist, GSK1521498, in obese individuals with moderate binge eating. Subjects were tested during a baseline placebo run-in period and retested after 28-days of drug (n = 21) or placebo (n = 21) treatment. Using functional magnetic resonance imaging and behavioral measu

SUBMITTER: Cambridge VC 

PROVIDER: S-EPMC3898083 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature