Pre-eclampsia rates in the United States, 1980-2010: age-period-cohort analysis.

ABSTRACT:

Objective

To estimate the contributions of biological aging, historical trends, and birth cohort effects on trends in pre-eclampsia in the United States.

Design

Population based retrospective study.

Setting

National hospital discharge survey datasets, 1980-2010, United States.

Participants

120 million women admitted to hospital for delivery.

Main outcome measures

Temporal changes in rates of mild and severe pre-eclampsia in relation to maternal age, year of delivery, and birth cohorts. Poisson regression as well as multilevel age-period-cohort models with adjustment for obesity and smoking were incorporated.

Results

The rate of pre-eclampsia was 3.4%. The age-period-cohort analysis showed a strong age effect, with women at the extremes of maternal

SUBMITTER: Ananth CV 

PROVIDER: S-EPMC3898425 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature