Three-year outcomes of the surgery for trichiasis, antibiotics to prevent recurrence trial.

ABSTRACT:

Objective

To determine whether treatment with oral azithromycin compared with topical tetracycline reduces the recurrence of trichiasis for up to 3 years following surgery for trichiasis.

Methods

The Surgery for Trichiasis, Antibiotics to Prevent Recurrence (STAR) trial is a randomized, single-masked, clinical trial conducted in southern Ethiopia, a region where trachoma is hyperendemic. A total of 1452 patients who underwent trichiasis surgery were randomly assigned at a 2:1 ratio to either a single dose of oral azithromycin (1 g) or topical tetracycline (twice per day for 6 weeks) following surgery.

Main outcome measures

Recurrence of trichiasis within 3 years following surgery.

Results

The rate of recurrence was 10% in the azithromycin group and 13% in the t

SUBMITTER: Woreta F 

PROVIDER: S-EPMC3898462 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature