Long term duration of protective effect for HPV negative women: follow-up of primary HPV screening randomised controlled trial.

ABSTRACT:

Objectives

To assess whether the increased sensitivity of screening for human papillomavirus (HPV) may represent overdiagnosis and to compare the long term duration of protective effect against cervical intraepithelial neoplasia grade 2 or worse (CIN2+) in HPV based and cytology based screening.

Design

13 year follow-up of the Swedescreen randomised controlled trial of primary HPV screening.

Setting

Organised cervical screening programme in Sweden.

Participants

12,527 women aged 32-38 attending organised screening were enrolled and randomised to HPV and cytology double testing (intervention arm, n=6257) or to cytology only, with samples frozen for future HPV testing (control arm, n=6270).

Main outcome measures

Cumulative incidence of CIN2+ and CIN3+ (Kap

SUBMITTER: Elfstrom KM 

PROVIDER: S-EPMC3898575 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature