B-lymphocyte depletion with rituximab and β-cell function: two-year results.

ABSTRACT:

Objective

We previously reported that selective depletion of B-lymphocytes with rituximab, an anti-CD20 monoclonal antibody, slowed decline of β-cell function in recent-onset type 1 diabetes mellitus (T1DM) at 1 year. Subjects were followed further to determine whether there was persistence of effect.

Research design and methods

Eighty-seven subjects (aged 8-40 years) were randomly assigned to, and 81 received, infusions of rituximab or placebo on days 1, 8, 15, and 22. The primary outcome-baseline-adjusted mean 2-h area under the curve (AUC) serum C-peptide during a mixed-meal tolerance test (MMTT) at 1 year-showed higher C-peptide AUC with rituximab versus placebo. Subjects were further followed with additional MMTTs every 6 months.

Results

The rate of decline of C-

SUBMITTER: Pescovitz MD 

PROVIDER: S-EPMC3898764 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature