Genetic variants in microRNA target sites of 37 selected cancer-related genes and the risk of cervical cancer.

ABSTRACT:

Objectives

Single nucleotide polymorphisms (SNPs) in putative microRNA binding sites (miRSNPs) modulate cancer susceptibility via affecting miRNA binding. Here, we sought to investigate the association between miRSNPs and cervical cancer risk.

Methods

We first genotyped 41 miRSNPs of 37 cancer-related genes in 338 patients and 334 controls (Study 1), and replicated the significant associations in 502 patients and 600 controls (Study 2). We tested the effects of miRSNPs on microRNA-mRNA interaction by luciferase reporter assay.

Results

Five SNPs displayed notable association with cervical cancer risk in Study 1. Only IL-16 rs1131445 maintained a significant association with cervical cancer (CT/CC vs. TT, adjusted OR = 1.51, P = 0.001) in Study 2. This association was m

SUBMITTER: Mi Y 

PROVIDER: S-EPMC3899132 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature