The role of EMMPRIN expression in ovarian epithelial carcinomas.

ABSTRACT:

Purpose

Extracellular matrix metalloproteinase inducer (EMMPRIN) was reported to involve in the invasion and metastasis of malignancies by regulating the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in stromal and cancer cells. The study aimed to clarify the role of EMMPRIN expression in tumorigenesis and progression of ovarian epithelial carcinomas.

Methods

EMMPRIN siRNA were transfected into ovarian carcinoma cells with the phenotypes and their related molecules examined. EMMPRIN expression was determined in ovarian normal tissue, benign and borderline tumors, and epithelial carcinomas by real-time PCR, western blot, and immunohistochemistry.

Results

EMMPRIN siRNA treatment resulted in a lower growth, G 1 arrest, apopt

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC3899202 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature