Pathogenesis-targeted, disease-modifying therapies in Parkinson disease.

ABSTRACT: Parkinson disease is an inexorably progressive neurodegenerative disorder. Multiple attempts have been made to establish therapies for Parkinson disease which provide neuroprotection or disease modification-two related, but not identical, concepts. However, to date, none of these attempts have succeeded. Many challenges exist in this field of research, including a complex multisystem disorder that includes dopaminergic and non-dopaminergic features; poorly understood and clearly multifaceted disease pathogenic mechanisms; a lack of reliable animal models; an absence of effective biomarkers of disease state, progression, and target engagement; and the confounding effects of potent symptomatic therapy. In this article, we will review previous, ongoing, and potential future trials designed to

SUBMITTER: AlDakheel A 

PROVIDER: S-EPMC3899477 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature