An analysis of polymorphisms within the Wnt signaling pathway in relation to ovarian cancer risk in a Polish population.

ABSTRACT:

Background and objective

The Wnt/β-catenin signaling pathway has been considered to be a factor in the development and progression of ovarian cancer.

Methods

All patients with ovarian cancer and controls were tested for BRCA1 mutations (5382incC, C61G, 4153delA) with HybProbe assays and for BRCA2 mutation (5946delT) using high-resolution melting curve analysis (HRM). Mutation carriers were excluded from the association analysis. We studied nine single nucleotide polymorphisms (SNPs) located in CTNNB1 (β-catenin) [rs4533622, rs2953], APC (rs11954856, rs351771, rs459552), and AXIN2 (rs4074947, rs7224837, rs3923087, rs2240308) in women with ovarian cancer without BRCA1/BRCA2 mutations (n = 228) and controls (n = 282). Genotyping of CTNNB1 rs4533622, rs2953, APC rs351771, AXIN2

SUBMITTER: Mostowska A 

PROVIDER: S-EPMC3899496 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature