Environmental enrichment strengthens corticocortical interactions and reduces amyloid-β oligomers in aged mice.

ABSTRACT: Brain aging is characterized by global changes which are thought to underlie age-related cognitive decline. These include variations in brain activity and the progressive increase in the concentration of soluble amyloid-β (Aβ) oligomers, directly impairing synaptic function and plasticity even in the absence of any neurodegenerative disorder. Considering the high social impact of the decline in brain performance associated to aging, there is an urgent need to better understand how it can be prevented or contrasted. Lifestyle components, such as social interaction, motor exercise and cognitive activity, are thought to modulate brain physiology and its susceptibility to age-related pathologies. However, the precise functional and molecular factors that respond to environmental stimuli and mi

SUBMITTER: Mainardi M 

PROVIDER: S-EPMC3899529 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature