Does reduced creatine synthesis protect against statin myopathy?

ABSTRACT: Statins, widely used to lower cholesterol levels, cause myopathy in some patients. Mangravite et al. (2013) show that a single nucleotide polymorphism decreasing expression of glycine amidinotransferase (GATM), the enzyme regulating creatine biosynthesis, is associated with reduced statin myopathy. Whether reduced creatine production protects against statin myopathy remains to be determined.

SUBMITTER: Ballard KD 

PROVIDER: S-EPMC3899594 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature