Predictive value of miR-9 as a potential biomarker for nasopharyngeal carcinoma metastasis.

ABSTRACT:

Background

Nasopharyngeal carcinoma (NPC) has a distinctive geographic distribution and is characterised by its strong tendency of metastasis. We aimed to examine the microRNA (miRNA) expression profiles in plasma samples of NPC patients to explore their clinical significance in disease development and progression.

Methods

This study was divided into four steps: (1) confirmation of differentially expressed miRNAs using microarray analysis and quantitative PCR validation; (2) comparison of plasma miR-9 levels during NPC progression; (3) evaluation of the predictive performance of plasma miR-9 as a biomarker for NPC metastasis; and (4) comparison of plasma miR-9 levels between pre- and post-treatment samples.

Results

Plasma microarray profiling identified 33 differentia

SUBMITTER: Lu J 

PROVIDER: S-EPMC3899774 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature