Key differences identified between actinic keratosis and cutaneous squamous cell carcinoma by transcriptome profiling.

ABSTRACT:

Background

Cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in fair-skinned populations worldwide and its incidence is increasing. Despite previous observations of multiple genetic abnormalities in cSCC, the oncogenic process remains elusive. The purpose of this study was to elucidate key molecular events associated with progression from premalignant actinic keratoses (AKs) to invasive cSCC by transcriptome profiling.

Methods

We combined laser capture microdissection with the Affymetrix HGU133 Plus 2.0 microarrays to profile 30 cSCC and 10 AKs.

Results

We identified a core set of 196 genes that are differentially expressed between AK and cSCC, and are enriched for processes including epidermal differentiation, cell migration, cell-cycle

SUBMITTER: Lambert SR 

PROVIDER: S-EPMC3899778 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature