Discriminating gene expression signature of radiation-induced thyroid tumors after either external exposure or internal contamination.

ABSTRACT: Both external radiation exposure and internal radionuclide contamination are well known risk factors in the development of thyroid epithelial tumors. The identification of specific molecular markers deregulated in radiation-induced thyroid tumors is important for the etiological diagnosis since neither histological features nor genetic alterations can discriminate between sporadic and radiation-induced tumors. Identification of highly discriminating markers in radiation-induced tumors is challenging as it relies on the ability to identify marker deregulation which is associated with a cellular stress that occurred many years before in the thyroid cells. The existence of such a signature is still controversial, as it was not found in several studies while a highly discriminating signature w

SUBMITTER: Ory C 

PROVIDER: S-EPMC3899964 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature