Mouse regenerating myofibers detected as false-positive donor myofibers with anti-human spectrin.

ABSTRACT: Abstract Stem cell transplantation is being tested as a potential therapy for a number of diseases. Stem cells isolated directly from tissue specimens or generated via reprogramming of differentiated cells require rigorous testing for both safety and efficacy in preclinical models. The availability of mice with immune-deficient background that carry additional mutations in specific genes facilitates testing the efficacy of cell transplantation in disease models. The muscular dystrophies are a heterogeneous group of disorders, of which Duchenne muscular dystrophy is the most severe and common type. Cell-based therapy for muscular dystrophy has been under investigation for several decades, with a wide selection of cell types being studied, including tissue-specific stem cells and reprogramme

SUBMITTER: Rozkalne A 

PROVIDER: S-EPMC3900004 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature