Combinatorial modeling of chromatin features quantitatively predicts DNA replication timing in Drosophila.

ABSTRACT: In metazoans, each cell type follows a characteristic, spatio-temporally regulated DNA replication program. Histone modifications (HMs) and chromatin binding proteins (CBPs) are fundamental for a faithful progression and completion of this process. However, no individual HM is strictly indispensable for origin function, suggesting that HMs may act combinatorially in analogy to the histone code hypothesis for transcriptional regulation. In contrast to gene expression however, the relationship between combinations of chromatin features and DNA replication timing has not yet been demonstrated. Here, by exploiting a comprehensive data collection consisting of 95 CBPs and HMs we investigated their combinatorial potential for the prediction of DNA replication timing in Drosophila using quantitat

SUBMITTER: Comoglio F 

PROVIDER: S-EPMC3900380 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature