Differential immune response associated to malaria outcome is detectable in peripheral blood following Plasmodium yoelii infection in mice.

ABSTRACT: Malaria infection in humans elicits a wide range of immune responses that can be detected in peripheral blood, but we lack detailed long-term follow-up data on the primary and subsequent infections that lead to naturally acquired immunity. Studies on antimalarial immune responses in mice have been based on models yielding homogenous infection profiles. Here, we present a mouse model in which a heterogeneous course of Plasmodium yoelii lethal malaria infection is produced in a non-congenic ICR strain to allow comparison among different immunological and clinical outcomes. Three different disease courses were observed ranging from a fatal outcome, either early or late, to a self-resolved infection that conferred long-term immunity against re-infection. Qualitative and quantitative changes pr

SUBMITTER: Azcarate IG 

PROVIDER: S-EPMC3900426 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature