The feline bile salt export pump: a structural and functional comparison with canine and human Bsep/BSEP.

ABSTRACT:

Background

The bile salt export pump (BSEP/ABCB11) is the primary transporter for the excretion of bile acids from hepatocytes into bile. In human, inhibition of BSEP by drugs has been related to drug-induced cholestasis and subsequent cytotoxic effects. The role of BSEP in canine and feline liver diseases has not been studied in detail, but the same mechanism of inhibition by drugs as in humans could play a role in veterinary medicine. The aim of this study was to investigate the functional characteristics of feline Bsep in comparison with canine and human Bsep/BSEP with respect to substrate affinities and inhibitory potential of model drugs. Orthologs of all three species were cloned and cell membrane vesicles overexpressing feline, canine and human Bsep/BSEP were prepared for fu

SUBMITTER: van Beusekom CD 

PROVIDER: S-EPMC3900472 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature