Discovery of new G-quadruplex binding chemotypes.

ABSTRACT: We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.

SUBMITTER: Ohnmacht SA 

PROVIDER: S-EPMC3901018 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature