Genome-wide association study of bipolar disorder in Canadian and UK populations corroborates disease loci including SYNE1 and CSMD1.

ABSTRACT:

Background

Recently, genome-wide association studies (GWAS) for cases versus controls using single nucleotide polymorphism microarray data have shown promising findings for complex neuropsychiatric disorders, including bipolar disorder (BD).

Methods

Here we describe a comprehensive genome-wide study of bipolar disorder (BD), cross-referencing analysis from a family-based study of 229 small families with association analysis from over 950 cases and 950 ethnicity-matched controls from the UK and Canada. Further, loci identified in these analyses were supported by pathways identified through pathway analysis on the samples.

Results

Although no genome-wide significant markers were identified, the combined GWAS findings have pointed to several genes of interest that suppor

SUBMITTER: Xu W 

PROVIDER: S-EPMC3901032 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature