Association studies including genotype by environment interactions: prospects and limits.

ABSTRACT:

Background

Association mapping studies offer great promise to identify polymorphisms associated with phenotypes and for understanding the genetic basis of quantitative trait variation. To date, almost all association mapping studies based on structured plant populations examined the main effects of genetic factors on the trait but did not deal with interactions between genetic factors and environment. In this paper, we propose a methodological prospect of mixed linear models to analyze genotype by environment interaction effects using association mapping designs. First, we simulated datasets to assess the power of linear mixed models to detect interaction effects. This simulation was based on two association panels composed of 90 inbreds (pearl millet) and 277 inbreds (maize).

R

SUBMITTER: Saidou AA 

PROVIDER: S-EPMC3901036 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature