Transcriptional regulation of CXCR4 in prostate cancer: significance of TMPRSS2-ERG fusions.

ABSTRACT:

Unlabelled

CXCR4 is a chemokine receptor that mediates invasion and metastasis. CXCR4 expression is transcriptionally regulated in cancer cells and is associated with aggressive prostate cancer phenotypes. Previously, we and others have shown that the transcription factor ERG regulates CXCR4 expression in prostate cancer cells and that androgens modulate CXCR4 expression via increasing ERG expression. Herein, the molecular mechanisms of ERG-mediated CXCR4 promoter activation, phosphorylation of ERG by intracellular kinases and subsequent CXCR4 expression, as well as the status of ERG and CXCR4 in human prostate cancer specimens were investigated. Using multiple molecular strategies, it was demonstrated that (i) ERG expressed in TMPRSS2-ERG fusion positive VCaP cells selectively bin

SUBMITTER: Singareddy R 

PROVIDER: S-EPMC3901058 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature