Comparative Chemistry of Aspergillus oryzae (RIB40) and A. flavus (NRRL 3357).

ABSTRACT: Aspergillus oryzae and A. flavus are important species in industrial biotechnology and food safety and have been some of the first aspergilli to be fully genome sequenced. Bioinformatic analysis has revealed 99.5% gene homology between the two species pointing towards a large coherence in the secondary metabolite production. In this study we report on the first comparison of secondary metabolite production between the full genome sequenced strains of A. oryzae (RIB40) and A. flavus (NRRL 3357). Surprisingly, the overall chemical profiles of the two strains were mostly very different across 15 growth conditions. Contrary to previous studies we found the aflatrem precursor 13-desoxypaxilline to be a major metabolite from A. oryzae under certain growth conditions. For the first time, we addit

SUBMITTER: Rank C 

PROVIDER: S-EPMC3901201 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature