Associations between interleukin-1 gene polymorphisms and sepsis risk: a meta-analysis.

ABSTRACT:

Background

Previous epidemiological studies have presented conflicting evidence regarding associations between interleukin-1 (IL-1) polymorphisms and sepsis susceptibility. We have performed a meta-analysis to evaluate possible associations between IL-1 polymorphisms and sepsis risk.

Methods

Eligible literature was retrieved from PubMed, Embase and Web of Knowledge databases until Jun 15, 2013. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using random-effects model in the overall and subgroup analysis based on ethnicity, sepsis severity and quality score.

Results

Eighteen studies addressing five IL-1 polymorphisms were included in this meta-analysis. For IL-1A-889 (rs1800587) polymorphism, significant association was observed in overall

SUBMITTER: Zhang AQ 

PROVIDER: S-EPMC3901334 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature