Esophageal adenocarcinoma incidence in individuals with gastroesophageal reflux: synthesis and estimates from population studies.

ABSTRACT:

Objectives

Recent advances in the management of Barrett's esophagus may kindle enthusiasm for screening for esophageal adenocarcinoma (EAC). Symptoms of gastroesophageal reflux disease (GERD) are recognized as relative risks for EAC. However, the absolute incidence of EAC in specific populations with GERD is unknown. We aimed to estimate the symptom-, age-, and sex-specific incidences of EAC, and place these incidences in the perspective of other cancers for which screening is endorsed.

Methods

A Markov computer model utilizing published and publicly available data was created to estimate the age- and sex-specific incidences of EAC in American white non-Hispanics with GERD symptoms.

Results

The incidence of EAC in men younger than 50 years with GERD symptoms is very l

SUBMITTER: Rubenstein JH 

PROVIDER: S-EPMC3901355 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature