Large fluctuations in the effective population size of the malaria mosquito Anopheles gambiae s.s. during vector control cycle.

ABSTRACT: On Bioko Island, Equatorial Guinea, indoor residual spraying (IRS) has been part of the Bioko Island Malaria Control Project since early 2004. Despite success in reducing childhood infections, areas of high transmission remain on the island. We therefore examined fluctuations in the effective population size (N e ) of the malaria vector Anopheles gambiae in an area of persistent high transmission over two spray rounds. We analyzed data for 13 microsatellite loci from 791 An. gambiae specimens collected at six time points in 2009 and 2010 and reconstructed the demographic history of the population during this period using approximate Bayesian computation (ABC). Our analysis shows that IRS rounds have a large impact on N e , reducing it by 65%-92% from prespray round N e . More importantly,

SUBMITTER: Hodges TK 

PROVIDER: S-EPMC3901547 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature