Genome sequence of Anopheles sinensis provides insight into genetics basis of mosquito competence for malaria parasites.

ABSTRACT:

Background

Anopheles sinensis is an important mosquito vector of Plasmodium vivax, which is the most frequent and widely distributed cause of recurring malaria throughout Asia, and particularly in China, Korea, and Japan.

Results

We performed 454 next-generation sequencing and obtained a draft sequence of A. sinensis assembled into scaffolds spanning 220.8 million base pairs. Analysis of this genome sequence, we observed expansion and contraction of several immune-related gene families in anopheline relative to culicine mosquito species. These differences suggest that species-specific immune responses to Plasmodium invasion underpin the biological differences in susceptibility to Plasmodium infection that characterize these two mosquito subfamilies.

Conclusions

The A.

SUBMITTER: Zhou D 

PROVIDER: S-EPMC3901762 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature